Wonder Boys became a movie; The Amazing Adventures of Kavalier and Clay took the Pulitzer Prize. Michael Chabon has followed these with an alternate-history mystery set in the noir world of the Alaskan shetls.
A few critics have expressed surprise that their darling would write a book that could be considered both SF and mystery, but the rest of us understand that Real WritersTM can and do write genre. The Yiddish Policemen’s Union has been nominated for and Edgar Award and the 2008 Hugo. A film by the Coen Brothers is in pre-production.